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KMID : 0043319880110020155
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Archives of Pharmacal Research
1988 Volume.11 No. 2 p.155 ~ p.158
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Binding Properties of Guanosine-2’’,3’’,5’’-triisobutyrate
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Yu BS
Kim KM/Sohn DH
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Abstract
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To study the behavior of nucleic acid base in a nonpolar organic solvent, chloroform, we synthesized a derivative of guanosine. This derivative, guanosine-2’’,3’’,5’’-triisobutyrate was obtained by reaction of guanosine with isobutyric anhydride, and identified by TLC, EA, IR and NMR. Hydrogen bonding specificity of this compound was revealed by IR and NMR. The molecules of guanosine-2’’,3’’,5’’-triisobutyrate are self-associated in non-polar solvent, and hydrogen bonds by imino protons become important as the concentration increases. In the presence of a cytosine derivative, the self-association of the guanosine derivative is destroyed, resulting from interaction with cytosine derivative.
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